Dynamic binding of a ubiquitin binding domain to polyubiquitin stimulates chain elongation by an E2 enzyme

Coupling of ubiquitin conjugation to ER degradation protein 1 (Cue1)
Residues 41-44 represent non-native residues (cloning artifacts). Residues 45-115 represent native amino acids of yeast Cue1.

Structure of the CUE domain of yeast coupling of ubiquitin conjugation to ER degradation protein 1 (Cue1)
Structure of the CUE domain of yeast Cue1

Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7 to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination.