Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide

(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid

Dynamically coupled residues within the SH2 domain of FYN are key to unlock its activity

The SH2 domain from human p59fyn is represented by residues149W-248K. The construct has a 22 N-term tag.

natural inhibitory phosphotyrosine peptide

Nmr Structure Of The Fyn Sh2 Domain Complexed With A Phosphotyrosyl Peptide, Minimized Average Structure

Nmr Structure Of The Fyn Sh2 Domain Complexed With A Phosphotyrosyl Peptide, 22 Structures

Swapped Dimer Of The Human Fyn-sh2 Domain

Human Fyn-sh2 Domain In Complex With A Synthetic High-affinity Phospho-peptide

protein-tyrosine kinase fyn isoform a [Homo sapiens]

FYN oncogene related to SRC, FGR, YES [synthetic construct]

src-like tyrosine kinase (put.); putative [Homo sapiens]

FYN oncogene related to SRC, FGR, YES [Homo sapiens]

tyrosine-protein kinase Fyn [Bos taurus]

tyrosine-protein kinase Fyn [Sus scrofa]

tyrosine-protein kinase Fyn [Xenopus laevis]

proto-oncogene tyrosine-protein kinase fyn [Xenopus laevis]

tyrosine-protein kinase Fyn isoform a [Mus musculus]

RecName: Full=Tyrosine-protein kinase Fyn; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=p59-Fyn

RecName: Full=Tyrosine-protein kinase Fyn; AltName: Full=Proto-oncogene Syn; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=

TPA: proto-oncogene tyrosine-protein kinase Fyn [Bos taurus]

The SH2 domain from human p59fyn is represented by residues149-248.

The natural inhibitory peptide is a 10 residues phosphotyrosine segment from the C-terminal region of the Fyn kinase.

simulated annealing, simulated annealing

Fyn SH2 in complex with the high affinity inhibitory peptide

Fyn SH2 domain bound to the natural inhibitory peptide

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax

Brunger, Adams, Clore, Gros, Nilges and Read