Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

Dot1L Histone-lysine N-methyltransferase

Dot1L Histone lysine N-methyltransferase

Solution Structure Of The Af4-af9 Complex

Solution Nmr Structure Of Dot1l In Complex With Af9 (dot1l-af9)

unnamed protein product [Oncorhynchus mykiss]

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 [Homo sapiens]

RecName: Full=Protein AF-9; AltName: Full=Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homol

RecName: Full=Protein AF-9; AltName: Full=ALL1-fused gene from chromosome 9 protein; AltName: Full=Myeloid/lymphoid or mixed-li

TPA: myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog [Bos taurus]

Thioredoxin Coding Region was inserted into pETduet-1 vector to increase expression

simulated annealing, SIMULATED ANNEALING, SIMULATED ANNEALING

Solution NMR structure of the AF4-AF9 complex

Histone-lysine N-methyltransferase, H3 lysine-79 specific

(3-acrylamidopropyl)-trimethylammonium chloride

Reverse Transcriptase Polymerase Chain Reaction

Schwieters, Kuszewski, Tjandra and Clore

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax