Abl 1b isoform E528K SH3-SH2-KD (aa 83-534) apo

ABL1 regulatory core SH3-SH2-Kinase domain (83-534) with point mutation E528K

Abl kinase domain in complex with PD173955

Abl kinase domain in complex with imatinib

The molecular basis of Abelson kinase regulation by its αI-helix.

Abelson tyrosine kinase, cancer, chronic myelogenous leukemia, allosteric activation, aI-helix, asciminib, NMR

ABL1 E528K SH3-SH2-Kinase Domain (residues 83-534, isoform 1b)
point mutation E528K; first two amino acids (GP) from cleavage site

co-expression with phosphatase PTP1 plus a separate plasmid that expresses lamda phosphatase (LPP)

subdirectory nmr_p has NMRPipe processing file and subdirectory add_files contains all Bruker list files and the pulse program

Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) apo

Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with asciminib

Abl 1b isoform wild type SH3-SH2-KD (aa 83-519) apo

Abl 1b isoform wild type SH3-SH2-KD (aa 83-519) in complex with imatinib

Abl 1b isoform wild type SH3-SH2-KD (aa 83-517) apo

Abl 1b isoform wild type SH3-SH2-KD (aa 83-517) in complex with imatinib

Abl 1b isoform wild type SH3-SH2-KD (aa 83-515) apo

Abl 1b isoform wild type SH3-SH2-KD (aa 83-515) in complex with imatinib

Abl 1b isoform E528K SH3-SH2-KD (aa 83-534) in complex with imatinib

Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with GNF-5

Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with PD166326

Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with imatinib