Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain complexed to olaparib

4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one

C24 H23 F N4 O3

separate tube (no insert) similar to the experimental sample tube

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.

The first residue in the sequence supplied here is a non-native glycine arising
from cloning.
The remaining residues are residues 656-1014 of human PARP-1 (the isoform having
Ala at position 762).

2D 1H-15N TROSY-based steady-state 15N{1H} NOE measurement

2D 1H-15N TROSY-based 15N T1 measurement

2D 1H-15N TROSY-based 15N T1rho measurement

The pulse sequences used are those described in:
Lakomek et al. (2012), J. Biomol. NMR, 53, 209-21.

The pulse sequences used are those described in:
Lakomek et al. (2012), J. Biomol. NMR, 53, 209-21.
The B1 field strength and offset for the T1rho experiments
were 1.56 KHz and 117.074 ppm respectively.
The T1rho values given here are all corrected for 15N offset
using equation (1) of Lakomek et al.

human PARP-1 CAT domain HN, N, CA and CB assignments and backbone amide group 15N relaxation data

Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain complexed to veliparib

Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain complexed to talazoparib

Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain complexed to EB-47

Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain L765F mutant

Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain L765A mutant

Backbone amide group 15N and 1H assignments and 15N relaxation data for human PARP-1 CAT domain L713F mutant