Retracted state of S65-phosphorylated ubiquitin

(2S)-2-amino-3-phosphonooxy-propanoic acid

Proceedings of the National Academy of Sciences of the United States of America
Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch.

Relaxed state of S65-phosphorylated ubiquitin

0.8 mM [U-98% 13C; U-98% 15N] phosphorylated ubiquitin, 90% H2O/10% D2O

pH-sensitive ubiquitin conformational switch

Schwieters, Kuszewski, Tjandra and Clore