Solution structure of the Pin1-PPIase (S138A) mutant

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (E.C.5.2.1.8)

Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1.

Peptidyl-prolyl cis-trans isomerase Pin1

DGSA-distance geometry simulated annealing

1 mM [U-13C; U-15N] Pin1 PPIase S138A mutant, 50 mM sodium phosphate, 100 mM sodium sulfate, 5 mM EDTA, 1 mM DTT, 0.03 % sodium azide, 6 % [U-2H] D2O, 94% H2O/6% D2O

Schwieters, Kuszewski, Tjandra and Clore

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax