Solution NMR structure and dynamics of human Brd3 ET in complex with MLV IN CTD

Integrase, Bromodomain-containing protein 3

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.

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0.25 mM [U-100% 13C; U-100% 15N] Brd3 ET, 0.25 mM [U-100% 13C; U-100% 15N] MLV-IN-CTD,
20 mM sodium phosphate, 100 mM sodium chloride, 2 mM 2-mercaptoethanol, 90% H2O/10% D2O

0.25 mM [U-15N] Brd3 ET, 0.25 mM [U-15N] MLV-IN-CTD,
20 mM sodium phosphate, 100 mM sodium chloride,
2 mM 2-mercaptoethanol, 90% H2O/10% D2O

Lee, Bahrami, Dashti, Eghbalnia, Tonelli, Westler and Markley

Zimmerman, Moseley, Kulikowski and Montelione

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax

Brunger, Adams, Clore, Gros, Nilges and Read