Solution structure of TDP-43 N-terminal domain dimer.

The ambiguity code for most assignments is 1; the assignments are not stereo-specific.
The ambiguity code will be 2 for all geminal atoms or geminal methyls, and 3 for all aromatic side-chains.

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Schwieters, Kuszewski, Tjandra and Clore
Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax