Backbone and Partial Side-Chain Chemical Shift Assignments and Dynamics
Measurements for The Catalytic Domain of Human Prolyl Hydroxylase Domain
2 (PHD2) With Zn(II), 2-Oxoglutarate (2OG) and Hypoxia Inducible Factor-alpha
(HIF-alpha) Peptide

Chemical communications (Cambridge, England)
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

The first six amino acids of the sequence (GSHMAS) are non-native N-terminal
residues that remained from thrombin protease cleavage of poly-histidine tag.
The rest of the sequence represents the catalytic domain of PHD2 (residues
181-402).

Hypoxia Inducible Factor-Alpha (HIF-alpha) Peptide. Substrate

Department of Chemistry, University of Oxford