Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA

MBD4 methyl-cytosine binding domain bound to methylated DNA

2'-deoxy-5-methylcytidine 5'-(dihydrogen phosphate)

[(2R,3S,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methyl dihydrogen phosphate

Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.

Crystal Structure Mbd4 Mbd Domain In Complex With Methylated Cpg Dna

unnamed protein product [Macaca fascicularis]

methyl-CpG-binding domain protein 4 [Pan troglodytes]

methyl-CpG binding protein MBD4 [Homo sapiens]

methyl-CpG binding endonuclease [Homo sapiens]

methyl-CpG binding protein 4 [Homo sapiens]

methyl-CpG binding domain protein 4 [Homo sapiens]

methyl-CpG-binding domain protein 4 [Pongo abelii]

methyl-CpG-binding domain protein 4 isoform 2 [Homo sapiens]

methyl-CpG-binding domain protein 4 isoform 3 [Homo sapiens]

methyl-CpG-binding domain protein 4 isoform 4 [Homo sapiens]

RecName: Full=Methyl-CpG-binding domain protein 4; AltName: Full=Methyl-CpG-binding endonuclease 1; AltName: Full=Methyl-CpG-bi

Schwieters, Kuszewski, Tjandra and Clore

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax