A novel design concept: New Y-receptor agonists with increased membrane recruitment, Y2 affinity and selectivity

Journal of peptide science : an official publication of the European Peptide Society
Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36.

designed peptide with GPCR subtype specificity

Structure of a (3-36)PYY mutant for improved membrane-binding affinity and improved Y2 receptor binding in presence of a membrane model (DPC)

Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollman