High-resolution solution structure of the ASIC1a blocker PcTX1

Protein science : a publication of the Protein Society
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.

Residue 1 is a vestige of the TEV cleavage site used for recombinant production of the protein.

Solution Structure Of Psmalmotoxin 1, The First Characterized Specific Blocker Of Asic1a Na+ Channel

Structure Of Chicken Acid-Sensing Ion Channel 1 At 3.0 A Resolution In Complex With Psalmotoxin

Crystal Structure Of Acid-Sensing Ion Channel In Complex With Psalmotoxin 1 At Low Ph

Crystal Structure Of Acid-Sensing Ion Channel In Complex With Psalmotoxin 1 At High Ph

RecName: Full=Pi-theraphotoxin-Pc1a; Short=Pi-TRTX-Pc1a; AltName: Full=PcTx1; AltName: Full=Psalmotoxin-1

Peptide toxin from the venom of the Trinidad chevron tarantula Psalmopoeus cambridgei

This structure was determined using a combination of NOESY-derived distance
restraints, TALOS-derived dihedral-angle restraints, and hydrogen-bond
restraints derived from a long-range HNCO experiment.

0.3 mM protein sample dissolved in 10 mM sodium phosphate buffer, pH 6.0