Backbone 1H, 15N, 13CO and 13CA resonance assignment of ABL kinase domain in complex with imatinib

signal transdcution pathways, misregulation leads to Leukemia

Backbone resonance assignment of the the ABL-imatinib complex is reported.

1H, 15N and 13C are referenced relative to the frequency of the 2H lock resonance of water

Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib.

GAMDP comes as cloning artifact. Real sequence starts from S229 to S500.

Crystal Structure Of Abl Kinase Domain In Complex With A Small Molecule Inhibitor

Crystal Structure Of The C-Abl Kinase Domain In Complex With Sti-571.

Crystal Structure Of The C-Abl Kinase Domain In Complex With Pd173955

Structural Basis For The Auto-Inhibition Of C-Abl Tyrosine Kinase

Crystal Structure Of The C-Abl Kinase Domain In Complex With Inno-406

Structure Of The Kinase Domain Of An Imatinib-Resistant Abl Mutant In Complex With The Aurora Kinase Inhibitor Vx-680

Organization Of The Sh3-Sh2 Unit In Active And Inactive Forms Of The C-Abl Tyrosine Kinase

A Src-Like Inactive Conformation In The Abl Tyrosine Kinase Domain

X-Ray Crystal Structure Of Dasatinib (Bms-354825) Bound To Activated Abl Kinase Domain

Crystal Structure Of Inactive Conformation Abl Kinase Catalytic Domain Complexed With Type Ii Inhibitor

Human Abl Kinase Domain In Complex With Imatinib (Sti571, Glivec)

Abl Kinase Domain In Complex With Nvp-Aeg082

Abl Kinase Domain Unligated And In Complex With Tetrahydrostaurosporine

Abl Kinase Domain In Complex With Pd180970

Abl Kinase Domain In Complex With Nvp-Afg210

Crystal Structure Of Abl Kinase Bound With Ppy-a

Crystal Structure Of The T315i Abl Mutant In Complex With The Inhibitor Pha-739358

Crystal Structure Of The T315i Mutant Of Abl Kinase Bound With Ppy-A

Human Abl Kinase In Complex With Nilotinib

Crystal Structure Of Mutant Abl Kinase Domain In Complex With Small Molecule Fragment

Ap24534, A Pan-Bcr-Abl Inhibitor For Chronic Myeloid Leukemi Potently Inhibits The T315i Mutant And Overcomes Mutation-B Resist

Structure Of Abl Kinase In Complex With Imatinib And Gnf-2

Structural Analysis Of Dfg-In And Dfg-Out Dual Src-Abl Inhibitors Sharing A Common Vinyl Purine Template

Abl Kinase In Complex With Imatinib And A Fragment (Frag1) I Myristate Pocket

Abl Kinase In Complex With Imatinib And Fragment (Frag2) In The Myristate Site

Crystal Structure Of Abl Kinase Domain Bound With A Dfg-Out Inhibitor Ap24534

Crystal Structure Of Abl T315i Mutant Kinase Domain Bound With A Dfg- Out Inhibitor Ap24589

Discovery And Characterization Of A Cell-Permeable, Small-Molecule C- Abl Kinase Activator That Binds To The Myristoyl Binding

The Crystal Structure Of Human Abl1 Kinase Domain In Complex With Dcc- 2036

The Crystal Structure Of Human Abl1 Kinase Domain T315i Mutant In Complex With Dcc-2036

The Crystal Structure Of Human Abl1 Kinase Domain In Complex With Dp- 987

Structural And Spectroscopic Analysis Of The Kinase Inhibitor Bosutinib Binding To The Abl Tyrosine Kinase Domain

The Crystal Structure Of Human Abl1 T315i Gatekeeper Mutant Kinase Domain In Complex With Axitinib

The Crystal Structure Of Human Abl1 Wild Type Kinase Domain In Complex With Axitinib

Crystal Structure Of An Sh2-kinase Domain Construct Of C-abl Tyrosine Kinase

v-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant [Homo sapiens]

Proto-oncogene tyrosine-protein kinase ABL1 variant [Homo sapiens]

unnamed protein product [Abelson murine leukemia virus]

unnamed protein product [Oncorhynchus mykiss]

proto-oncogene tyrosine-protein kinase [Homo sapiens]

p120 polyprotein [Abelson murine leukemia virus]

tyrosine-protein kinase ABL1 [Rattus norvegicus]

tyrosine-protein kinase ABL1 isoform a [Mus musculus]

tyrosine-protein kinase ABL1 [Bos taurus]

tyrosine-protein kinase ABL1 isoform c [Mus musculus]

tyrosine-protein kinase ABL1 isoform d [Mus musculus]

RecName: Full=Tyrosine-protein kinase ABL1; AltName: Full=Abelson murine leukemia viral oncogene homolog 1; AltName: Full=Abels

RecName: Full=Tyrosine-protein kinase transforming protein Abl; AltName: Full=V-abl

TPA: arg tyrosine kinase-like [Bos taurus]

Fusion protein, present in patients suffering from Leukemia.

Novartis Institutes of Biomedical Research, Basel

1H-15N HSQC of 15N-selectively labeled samples were recorded under the same sample conditions on spectrometer_3 or spectrometer_4. All the 3D experiments were recorded under the non-TROSY conditions.

Equipped with TCI cryoprobe
triple resonance, tripe-axis pulsed field gradient probes

Equipped with triple resonance, tripe-axis pulsed field gradient probes

Crystal structure of ABL kinase domain in complex with imatinib (Nagar et al. 2002, Can. Res.)

Identical conditions were used in the preparation of selectively labeled ABL-imatinib samples.Following 15N labeled samples were produced: Ala, Gly, Ile, Leu, Met, Phe, Thr, Trp , Tyr , Val to overcome ambiguity.

Both Uniformly 13C,15N and uniformly 15N labeled samples are prepared at the same conditions

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax